Job Title
Research Scientist III, Protein Sciences
Job Profile
The Research Scientist III will provide leadership to the protein purification group in Discovery Research for developing, optimizing purification protocols, execute experiments at the lab bench, manage work flow to assure timely delivery of reagents needed for in-vitro and in-vivo preclinical experiments (75%) and will contribute to identification, proposal and review of new therapeutic target opportunities (25%).
Principal Responsibilities
Manage and maintain state-of-the art protein purification laboratory in Discovery Research
2. Provide leadership to the protein purification group, direct and supervise Research Associates, manage work flow to assure timely delivery of reagents as required for in-vitro and in-vivo preclinical experiments
3. Develop, optimize and execute purification protocols for proteins (recombinant or from natural sources) so as to meet the required level of quality and quantity, in support of Discovery Research programs
4. Characterize proteins for purity, identity, integrity and function
5. Project experimental timelines at the inception of programs and complete the objectives within the agreed upon time frame
6. Collaborate closely with ‘Process Science’ to ensure smooth transition of protocols for upstream development
7. Participate in the identification and triage of new therapeutic target opportunities
8. Provide updates at project team and managers meetings
9. Maintain records in electronic notebooks in accordance with the ELN policy, and assure compliance by the group members
10. Write/edit ‘Technical Reports’ in support of IND applications
Qualifications
The Research Scientist III should have 4 – 8 years of relevant industrial/postdoctoral experience including leadership responsibilities
Exhibit a sound understanding of the theory governing macromolecular behavior
Demonstrated ability of developing, optimizing and executing purification methods for new proteins obtained from recombinant systems (mammalian or bacterial) or natural sources (e.g. serum).
Deep understanding of chromatographic techniques and principles governing them
Deep understanding of biophysical and biochemical techniques used for protein characterization
Knowledge in enzymology, protein structures, protein structure-function relationships
Experience in collaborating/directing/managing within a matrix research organization desirable
Ability to effectively allocate effort amongst multiple projects and drive to aggressive timelines
Bibliography consistent with high quality seminal research
Good oral and written communication skills
Education
Ph.D.or equivalent degree in Biology, Biochemistry, Enzymology, Structural Biology or related discipline, with 4 – 8 years of relevant postdoctoral or industrial experience
Competencies
Decision Quality
Problem Solving
Perseverance
Functional/Technical Skills
Intellectual Horsepower
Creativity
Priority Setting
Planning
Learning on the Fly
Presentation Skills
The candidate must:
As a leading employer in our industry, Alexion is proud to offer a highly competitive package of base and incentive compensation as well as a comprehensive benefits program designed to support the health, wellness and financial security of our employees and their families. Benefits include group medical, vision and dental coverage, group and supplemental life insurance, 401(k) with company match, tuition reimbursement, relocation assistance and much more. To learn more about Alexion, please visit ****or download our App for iPhones and Blackberries.
Alexion is an Equal Opportunity /Affirmative action employer
*LI-WM1
|
|
|
Location: USA-CT-Cheshire |
|
|
 |
Posted on
Jul 27,2026 |
|
Company info
|
|
|
|
|
