Postdoctoral Scientist: Preclinical Pharmacology Team Cancer Biomarker Centre Defin

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Postdoctoral Scientist: Preclinical Pharmacology Team, Cancer Biomarker Centre Defining Mechanisms of Small Cell Lung Cancer Metastasis
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- Cancer Biomarker Centre
Location:
Manchester
Salary:
£32,868 to £42,717 per annum (dependent upon qualifications and experience)
Hours:
Full Time
Contract Type:
Fixed-Term/Contract
Placed On:
9th February 2023
Closes:
5th March 2023
Job Ref:
MI/23/05
Duration: Fixed term for 3 years (in the first instance)
About the role:
We seek an innovative and motivated post-doctoral scientist to conduct translational research on Small Cell Lung Cancer (SCLC) within the Cancer Biomarker Centre at the CRUK Manchester Institute, led by Prof Caroline Dive CBE. SCLC is highly aggressive and metastatic, resulting in a
Our research is underpinned by >60 comprehensively characterised Circulating Tumour Cell (CTC) patient derived explant models (CDX)1,2. CDX can be grown in vivo and cultured ex vivo, allowing genetic manipulation and function testing studies3. They recapitulate SCLC molecular heterogeneity when implanted subcutaneously or intrathoracically and metastasise to secondary sites observed in patients.
Background:
Approximately 80% of SCLC patients develop incurable brain metastases4, previously understudied due to lack of patient samples and (until now) patient-derived preclinical models. This project utilises SCLC CDX models where brain metastasis is robustly observed2, and benefits from pre-existing transcriptomic data (bulk RNAseq and single cell RNAseq) from tumour cells from implanted tumours, blood (CTCs) and brain. We aim to define the roles of candidate genes in tropism, metastasis founding and colonisation and benefits from our long-standing collaboration with neurosurgeon and metastasis expert Prof. Sheila Singh5.
1Hodgkinson et al., Nature Medicine (2014); 2Simpson et al., Nature Cancer (2020); 3Lallo et al., Clin Cancer Research (2018);4Ko et al., EMBO Mol Med (2020); 5Vora et al., J Neurooncol (2019)
About you:
You will be a highly motivated, proactive problem solver who relishes a challenge and will develop independent ideas for project direction and delivery. You will have a PhD in cancer biology, cell biology, molecular pharmacology, or a related discipline, and relevant experience in a cancer research laboratory. Prior experience in metastasis and/or lung cancer research is beneficial but not essential.
Why choose Cancer Research UK Manchester Institute?
The Cancer Research UK Manchester Institute ( ****), an Institute of **MEMBERS ONLY**SIGN UP NOW***. ( ****), is a world-leading centre for excellence in cancer research. The Institute is core funded by Cancer Research UK ( ****), the largest independent cancer research organisation in the world. On the 26 April 2026 The Paterson Building, which housed most of the Cancer Research UK (CRUK) Manchester Institute, suffered a fire resulting in significant damage. The rebuilding of our world-class research facilities is well underway, and we anticipate returning to our original site in Withington, Manchester (next to the Christie NHS Foundation Trust) in 2023. It is expected this role will commence following the relocation to our original site.
Our aim is to understand the fundamental basis of cancer and translate that knowledge to developing new treatment strategies for cancer patients. Our advanced research programmes span a spectrum of cancer research, from the molecular and cellular basis of cancer through to drug discovery, translational research and clinical trials.
How to apply?
To apply for this position please visit our website: ****Informal enquiries should be directed to Professor Caroline Dive at ****
or to Preclinical Pharmacology Team Lead Dr Kathryn Simpson at ****
This vacancy will close for applications at 11:59pm on the 5 March 2023.
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