Associate Scientist II Downstream Process Development

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to **** Req ID: 31017 Job Category: Process
Development Location: New Haven, CT Posting Date: February 18,
2023 Some opportunities happen only once in a lifetime - like a job
where you have the chanceto change lives. At Alexion, people living with
rare and devastating diseases are our Guiding Star. We are driven to
continuously innovate and create meaningful value in all we do to help
patients and families fully live their best lives. We value the
uniqueness and diversity of our employees and recognize that nurturing
the diverse perspectives and strengths of our people translates into
innovative breakthroughs for patients. This is what you will do: The
Associate Scientist II is responsible for performing assigned
experimental tasks to support the development and optimization of
manufacturing processes for Alexion's biotherapeutic candidates. The
Associate Scientist II will work routinely in collaboration with other
members of Biologics Process Development, Technology Transfer and
Analytical Sciences, including all other groups in Product Development
and Clinical Supply. You will be responsible for:


Conducts experimental studies to develop, optimize, and characterize
manufacturing processes for biotherapeutic candidates
Executes experimental studies to support scale up of manufacturing
processes or troubleshooting of issues at manufacturing scale as
required for therapeutic proteins
Documents study results in notebooks, forms, and technical reports
Assists in laboratory management including ordering and maintenance


You will need to have:


BS (with 2 years of experience) or MS degree in Biochemistry,
Chemistry, Chemical Engineering or related discipline from an
accredited university
Problem solving skills: Works cross-functionally to solve routine
technical problems
Scientific Inquisitiveness: Understands background of assigned
technical tasks to be a resource for others, Demonstrates ability to
delve deeper into technical topics, Seeks to incorporate ideas from
conferences or literature into work processes
Communication skills: Routinely delivers effective technical
presentations within functional group, Drafts, edits and finalizes
technical documents without templatesand with minimal supervision,
Works collaboratively with own group to achieve shared objectives
Technical expertise: Conducts assigned routine tasks in the
laboratory with limited supervision, Carries out training in certain
technical areas, Executes complicated study plans with supervision
Decision Quality: Regularly interacts with peers across functions,
Understands priority of assigned tasks with limited supervision
Accountability: Works with supervisor and co-workers to ensure
assigned tasks are completed, Demonstrates ability to manage aspects
of a technical project
The duties of this role are generally conducted in an lab
environment. As is typical of a lab-based role, employees must be
able, with or without an acco modation to: lift/carry 15/30 pounds
unassisted/assisted; work comfortably in a controlled environment
with and around biological, infectious, and hazardous materials;
gown/degown PPE; use a computer; engage in communications via phone,
video, and electronic messaging; engage in problem solving and
non-linear thought, analysis, and dialogue; collaborate with others;
maintain general availability during standard business hours.


We would prefer for you to have:


Experience in any area of biologics process development (cell
culutre and/or purification) is preferred
Experience performing chromatographic protein purification is
preferred
Experience with Unicorn programming and operation of AKTA and other
chromatography skids is preferred
Experience in nano filtration and ultrafiltration/dialfiltration is
preferred
Proficiency with various MS Office programs, including Word, Excel,
Outlook, and PowerPoint is required
Experience with design of experiments and statistical software
packages (e.g. JMP) is preferred
Experience with hybrid or mechanistic modelling of bioseparations is
preferred


#LI-JR1 #LI-HYBRID Alexionis a global biopharmaceutical company focused
on serving patients and families affected by rare diseases and
devastating conditions through the discovery, development and
commercialization of life-changing medicines. Headquartered in Boston,
Massachusetts, Alexion has offices around the globe and serves patients
in more than 50 countries. Furtherinformation about Alexion can be found
at: ****. Alexion is proud to be an Equal Employment
Opportunity and Affirmative Action employer. We are committed to
fostering a culture of belonging where every single person can belong
because of their uniqueness. The Company will not make decisions about
employment, training, compensation, promotion, and other terms and
conditions of employment based on race, color, religion, creed or
lackthereof, sex, sexualorientation, age, ancestry, national origin,
ethnicity, citizenship status, marital status,pregnancy, (including
childbirth, breastfeeding, or related medical conditions), parental
status (including adoption or surrogacy), military status, protected
veteran status, disability, medical condition, gender identity or
expression, genetic information, mental illness or other characteristics
protected by law. Alexion has taken critical steps to protect
colleagues, loved ones, and patients from COVID-19 and its variants. All
US-based employees must comply with Alexion's COVID-19 vaccination
mandate. Alexion provides exceptions based on applicable state law as
well as reasonable accommodations to meet the needs of candidates and
employees. To begin aninteractive dialogue with Alexion regarding a
legally required exemption or accommodation, please contact
**** . Alexion participates in E-Verify. As a
leading employer in our industry, Alexion offers a highly competitive
package of base and incentive compensation as well as a comprehensive
benefits program designed to support the health, wellness and financial
security of our employees and their families. Benefits include group
medical, vision and dental coverage, group and supplemental life
insurance, 401(k) with company match, tuition reimbursement, and much
more. AstraZeneca completed its acquisition of Alexion, marking the
creation of Alexion, AstraZeneca Rare Disease. If you're interested in
career opportunities with AstraZeneca, click here . Alexion participates
in E-Verify process. To learn more, please click on attached document(s)
Apply Here: ****PI204580028

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