Associate Scientist II New Capabilities Downstream Process Development

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to **** Req ID: 30996 Job Category: Process
Development Location: New Haven, CT Posting Date: February 18,
2023 Some opportunities happen only once in a lifetime - like a job
where you have the chanceto change lives. At Alexion, people living with
rare and devastating diseases are our Guiding Star. We are driven to
continuously innovate and create meaningful value in all we do to help
patients and families fully live their best lives. We value the
uniqueness and diversity of our employees and recognize that nurturing
the diverse perspectives and strengths of our people translates into
innovative breakthroughs for patients. This is what you will do: The
Associate Scientist II is responsible for performing assigned
experimental tasks to support the implementation of the next generation
manufacturing platform for Alexion's biotherapeutic candidates. This
role resides within the New Capabilities Process Development group and
will be focused on the advancement of Alexion's manufacturing
capabilities through the development and integration of innovative
technologies. The Associate Scientist II will work routinely in
collaboration with other members of New Capabilities Process
Development, Biologics Process Development, Technology Transfer and
Analytical Sciences, including all other groups in Product Development
and Clinical Supply. You will be responsible for:


Evaluates new process development technologies via design and
execution of experimental plans
Communicates experimental results via technical talks at internal
meetings and external conferences
Conducts experimental studies to develop, optimize, and characterize
manufacturing processes for biotherapeutic candidates
Executes experimental studies to support scale up of manufacturing
processes or troubleshooting of issues at manufacturing scale as
required for therapeutic proteins
Documents study results in notebooks, forms, and technical reports
Assists in laboratory management including ordering and maintenance


You will need to have:


BS degree in Biology, Biochemistry, Chemistry, Chemical Engineering
or related discipline from an accredited university with 0- 1 years
of experience for MS or 2 years of experience with BS .
Understanding the fundamentals of biochemistry, chemistry and
chemical engineering
Strong learning agility and desire to learn new techniques
Good interpersonal, collaborative and communication skills
The duties of this role are generally conducted in an lab
environment. As is typical of a lab-based role, employees must be
able, with or without an accommodation to: lift/carry 15/30 pounds
unassisted/assisted; work comfortably in a controlled environment
with and around biological, infectious, and hazardous materials;
gown/degown PPE; use a computer; engage in communications via phone,
video, and electronic messaging; engage in problem solving and
non-linear thought, analysis, and dialogue; collaborate with others;
maintain genera availability during standard business hours


We would prefer for you to have:


Experience in any area of biologics process development (cell
culture and/or purification)
Experience of performing chromatographic protein purification
Experience with Unicorn programming and operation of AKTA and other
chromatography skids
Experience with Design of Experiments Software (e.g. JMP).
Understanding/coursework in the fundamentals of biochemistry and/or
protein chromatography
Demonstrated ability to perform routine laboratory work with an
understanding of laboratory safety and good documentation
An understanding of the principles behind cell culture,
chromatography, or filtration (TFF and NFF)


#LI-JR1 #LI-HYBRID Alexionis a global biopharmaceutical company focused
on serving patients and families affected by rare diseases and
devastating conditions through the discovery, development and
commercialization of life-changing medicines. Headquartered in Boston,
Massachusetts, Alexion has offices around the globe and serves patients
in more than 50 countries. Furtherinformation about Alexion can be found
at: ****. Alexion is proud to be an Equal Employment
Opportunity and Affirmative Action employer. We are committed to
fostering a culture of belonging where every single person can belong
because of their uniqueness. The Company will not make decisions about
employment, training, compensation, promotion, and other terms and
conditions of employment based on race, color, religion, creed or
lackthereof, sex, sexualorientation, age, ancestry, national origin,
ethnicity, citizenship status, marital status,pregnancy, (including
childbirth, breastfeeding, or related medical conditions), parental
status (including adoption or surrogacy), military status, protected
veteran status, disability, medical condition, gender identity or
expression, genetic information, mental illness or other characteristics
protected by law. Alexion has taken critical steps to protect
colleagues, loved ones, and patients from COVID-19 and its variants. All
US-based employees must comply with Alexion's COVID-19 vaccination
mandate. Alexion provides exceptions based on applicable state law as
well as reasonable accommodations to meet the needs of candidates and
employees. To begin aninteractive dialogue with Alexion regarding a
legally required exemption or accommodation, please contact
**** . Alexion participates in E-Verify. As a
leading employer in our industry, Alexion offers a highly competitive
package of base and incentive compensation as well as a comprehensive
benefits program designed to support the health, wellness and financial
security of our employees and their families. Benefits include group
medical, vision and dental coverage, group and supplemental life
insurance, 401(k) with company match, tuition reimbursement, and much
more. AstraZeneca completed its acquisition of Alexion, marking the
creation of Alexion, AstraZeneca Rare Disease. If you're interested in
career opportunities with AstraZeneca, click here . Alexion participates
in E-Verify process. To learn more, please click on attached document(s)
Apply Here: ****PI204580060

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