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Job Details

Principal Scientist Biotherapeutic Assay Development amp HT Screening


Cambridge, MA

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Cambridge, Massachusetts
Full Time - Experienced
Preferred Education:
The Principal Scientist,
Biotherapeutics Assay Development and High Throughput Screening (HTS),
will play a critical role in early biotherapeutic development programs by providing assay development and HT screening integration support. Specifically, the role will be collaborating with various Research Units within Pfizer to develop and integrate sensitive cell-based functional assays (such as utilizing reporter gene, HTRF, proliferation, apoptosis, internalization, second messenger and others as readout) in high throughput screening platform to facilitate biotherapeutic screening. The individual will also be asked to develop novel, sensitive, and relevant cell-based functional assays to address unmet drug screening needs.
Primary responsibilities include but not limited to:
Managing a team of assay development and screening scientists to advance Pfizer's biotherapeutic program
Collaborating with Lead discovery/generation scientists to identify desired biologics hits
Developing and adapting relevant and sensitive cell-based functional/reporter assays for screening biotherapeutic leads
Integrating biochemical and cell based functional assays into High Throughput Screening (HTS) workflow to existing biotherapeutic discovery platforms
Establishing and enhancing necessary infrastructure for HTS screening (SOPs, informatics, instrumentation, data recording and analytics)
Basic Qualifications
Ph.D. in Pharmacology, Biochemistry, Cell Biology, Immunology, or Molecular Biology with 3-5 years of relevant industrial experience required.
Demonstrated history of rigorous technical accomplishments and deep knowledge of common biologics screening platforms
Proven record of novel cell based reporter assay development in drug development
Experienced in various cell based functional assays (cell proliferation, apoptosis, differentiation, internalization, intracellular trafficking, etc)
Superior critical thinking and problem solving skills
Proven team management skills
Strong organizational and projects management skills
Excellent oral and written communication skills
Preferred Qualifications
Knowledge and expertise in biologics screening methods (single cells, hybridoma, or phage display) preferred
Expertise in integrated laboratory automation
Expertise in various High Content Screening (HCS) and High Throughput Screening (HTS) platforms
EEO & Employment Eligibility
Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.
Sunshine Act
Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider’s name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to ****
Eligible for Relocation Package
Eligible for Employee Referral Bonus

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