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Job Details

Scientist I Investigative Toxicology

Company name
Takeda Pharmaceutical Company Limited.

Boston, MA, United States

Employment Type

Sciences, Scientist, Pharmaceutical

Posted on
Jul 20, 2021

Valid Through
Nov 02, 2021

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Job Description

Are you looking for a patient-focused, innovation-driven company that will inspire you and empower you to shine? Join us as a Scientist I, Investigative Toxicology, in our Cambridge, Massachusetts office.

At Takeda, we are transforming the pharmaceutical industry through our R&D-driven market leadership and being a values-led company. To do this, we empower our people to realize their potential through life-changing work. Certified as a Global Top Employer, we offer stimulating careers, encourage innovation, and strive for excellence in everything we do. We foster an inclusive, collaborative workplace, in which our global teams are united by an unwavering commitment to deliver

Better Health and a Brighter Future

to people around the world.

Here, you will be a vital contributor to our inspiring, bold mission.

As a Scientist I, working on the DSRE, Investigative Toxicology team, you will be empowered to de

velop and implement innovative in vitro

assays to elucidate mechanisms of toxicities, improve risk assessment, and support Takeda’s diverse portfolio

.  A typical day will include:


Help us make safer therapies |

The Investigative Toxicology group is seeking a talented and highly motivated scientist with a background in molecular and cell biology and experience with in vitro

liver or cardiac models. The scientist will work as part of a cross functional team dedicated to delivering safer & more effective medicines to treat diseases with unmet medical need.

Deliver decision-making data |

The next generation of life changing medicines include oligonucleotides, gene and cell therapies. The successful candidate will develop and implement cutting-edge in vitro

assays to detect & de-risk toxicities for next generation medicines with an emphasis on cardio- or hepatotoxicity.

Help shape the next generation therapies |

The candidate will identify, evaluate, and implement new techniques and instrumentation to improve risk assessment and help shape the evolution of next generation therapies.


Develop and implement innovative in vitro

assays to elucidate mechanisms of toxicities, improve risk assessment, and support Takeda’s diverse portfolio.

Assess the safety of next generation medicines with an emphasis on cardio- and hepatoxicities.

Analyze and interpret experimental results and present findings at multidisciplinary project team meetings

Partner with key allied functions (e.g., DMPK, discovery scientists, process development) for strategic design and implementation of experimental plans and protocols

Provide a high level of subject matter expertise through familiarity with current scientific literature

Maintain detailed records of experimental protocols and data in an electronic laboratory notebook

Write and review technical reports, research protocols, SOPs, IND sections and scientific manuscripts for publication.


BS or MS in molecular or cell biology, toxicology or related discipline with 3 years of relevant research experience; OR PhD in immunology, cell biology, toxicology, or related discipline with 0 years of industry experience.

Experience working with in vitro

liver or cardiac models.

Mastery of conventional mammalian cell culture techniques (cell lines and primary cells) is essential.

Experience with high content imaging platforms and microscopy.

Ability to design and implement fit for purpose assays that provide insight into the mechanisms of drug-induced toxicity and inform mitigation strategies.

Strong interpersonal and organizational skills.

Excellent oral and written communication skills.

Ability to work independently as well as part of a cross-functional team.

Broad scientific knowledge including pharmacology, toxicology, pathology, physiology and biochemistry.

Experience working in a matrixed team environment at a pharmaceutical company and/or CRO

Experience working with novel therapeutic modalities including oligonucleotides, gene, and cell therapies

Familiarity with cutting-edge gene expression platforms (NGS, NanoString, 10x Genomics) and data analysis software

Experience with advanced cell culture techniques/micro physiological systems


DABT certification a plus, but not necessary

This job posting excludes CO applicants


401(k) with company match and Annual Retirement Contribution Plan

Tuition reimbursement

Company match of charitable contributions

Health & Wellness programs including onsite flu shots and health screenings

Generous time off for vacation and the option to purchase additional vacation days

Community Outreach Programs

Empowering Our People to Shine

Learn more at



Boston, MA

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