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Associate Principal Scientist Target Protein Design

West Point, PA

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Merck & Co., Inc. Kenilworth, N.J., U.S.A. known as Merck in the United States and Canada, is a global health care leader with a diversified portfolio of prescription medicines, vaccines and animal health products. The difference between potential and achievement lies in the spark that fuels innovation and inventiveness; this is the space where Merck has codified its 
legacy for over a century
. Merck’s success is backed by ethical integrity, forward momentum, and an inspiring mission to achieve new milestones in global healthcare.
Merck is on a quest for cures and is committed to being the world’s premier, most research-intensive biopharmaceutical company. Today, we’re doubling down on this goal. Merck Research Laboratories is a true scientific research facility of tomorrow, and will take Merck’s leading discovery capabilities and world-class small molecule and biologics R&D expertise to create breakthrough science that radically changes the way we approach serious diseases. 
A highly motivated candidate is sought to join the Target Protein Design group in the Department of Biochemical Engineering and Structural Sciences at our West Point, PA discovery site. This group utilizes multidisciplinary approaches to understand protein structure, function, and dynamics of novel drug targets in preparation for their advancement into our drug discovery pipeline.  The job requires the candidate to work in cross-functional discovery teams to understand the protein reagent needs of different functional areas and produce recombinant proteins to enable structure determination. Specific projects will involve cross-functional collaborations across diverse therapeutic areas that target proteins and pathways in oncology, immunology, cardiometabolic diseases, infectious disease, and neuroscience. This is a basic research position that requires critical thinking, flexibility, multitasking, and the ability to bring in new technologies to enable generation and characterization of difficult to express proteins.  
Education Minimum Requirement: 
Ph.D in Biochemistry, Biophysics, or related disciplines
Required Experience and Skills: 
Ph.D in Biochemistry, Biophysics, or related disciplines with >5 years experience and a strong publication record
Experience in biochemical/biophysical assay development (e.g. radioligand binding, HTRF, and BRET).
Experience in using automated plate-based assay platforms, liquid handling instrumentation, or multi-readout/format plate readers
Proficiency with biophysical techniques  to characterize protein stability, protein-ligand or protein-protein interactions (e.g. SPR, ITC,  DSC, DSF and MST) 
Proficiency with analytical techniques, such as LC-MS or protein conjugation/labeling
Excellent organizational skills with a demonstrated ability to devise protocols, document results, and prepare reports while executing on multiple projects concurrently
The successful candidate must have strong interpersonal skills and be highly motivated to work independently in a collaborative team-oriented setting
Strong analytical and communication skills with ability to effectively present scientific findings to project teams
Preferred Experience and Skills:
Experience in biochemical and biophysical characterization of challenging protein targets  such as integral membrane proteins, multi-protein complexes or protein-nucleic acid complexes for structure determination (e.g. X-ray crystallography or cryo-EM)
Background in enzyme kinetics, elucidating enzyme reaction mechanisms, and evaluating modes of small molecule enzyme inhibition or receptor-ligand interactions
Experience in construct design and recombinant protein expression/purification for biochemical assay development and biophysical studies 
Experience in using HDX-MS for characterization of protein-ligand interactions
Experience in using computational tools for homology modeling, de novo predictions, structure visualization and analysis, protein NMR and crystallography
Previous industrial experience desired but not required
Your role at Merck is integral to helping the world meet new breakthroughs that affect generations to come, and we’re counting on your skills and inventiveness to help make meaningful contributions to global medical advancement. At Merck, we’re inventing for life. 
If you need assistance and/or a reasonable accommodation due to a disability during the application or the recruiting process, please send a request to
Search Firm Representatives Please Read Carefully: 
Merck & Co., Inc. is not accepting unsolicited assistance from search firms for this employment opportunity.  Please, no phone calls or emails.  All resumes submitted by search firms to any employee at Merck via email, the Internet or in any form and/or method without a valid written search agreement in place for this position will be deemed the sole property of Merck.  No fee will be paid in the event the candidate is hired by Merck as a result of the referral or through other means.
For more information about personal rights under Equal Employment Opportunity, visit:
             EEOC Poster
             EEOC GINA Supplement 
Other Locations:
Employee Status:
Yes, 5 % of the Time
Number of Openings:
Shift (if applicable):
Hazardous Materials:
Standard research laboratory materials
Company Trade Name:
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