GENERAL SUMMARY/ OVERVIEW STATEMENT:
The incumbent will work within the TIMI Study Group, the oldest cardiovascular academic research organization in North America, to analyze data from ongoing genotyping & sequencing studies from our large scale randomized controlled trials focused on a broad spectrum of cardiovascular and metabolic diseases. It is envisioned the incumbent will spend 3 days a week at the TIMI Study Group at **MEMBERS ONLY**SIGN UP NOW***. and work with the Director of Biostatistics, other statisticians, and physician investigators. The other 2 days would be spent at the Broad Institute as part of TIMI's longstanding collaboration with cardiovascular geneticists and computational biologists there.
PRINCIPAL DUTIES AND RESPONSIBILITIES:
1.Collaborate with physician investigators to develop and perform computational analyses (including planning, programming, analysis, interpretation and writing of results) for investigational protocols, subgroup and post-hoc projects and registry databases ending with preparation of manuscripts, abstracts and presentations at scientific meetings.
2.Determine and/or verify correct computational testing to be performed in each analysis request.
3.Apply and develop computational pipelines to run genome-wide association studies, analyses of large scale genome sequencing data, and perform phenome-wide association studies.
4.Work with datasets from large-scale clinical trials and biobanks.
5.Define and extract phenotypes in collaboration with clinicians, establishing efficient computational pipeline to run association studies, fine mapping of results.
6.Conceive, implement and test statistical models and help analyze data from experiments.
7.Possess a solid understanding of the purpose, objectives and goals of each project.
8.Assure the maintenance of an up-to-date electronic archive recording data requests, computational analyses, results, and data transmissions performed.
9.Maintain department service standards as outlined in the BWH Code of Conduct
10.Performs other duties as required and as appropriate.
*MSc or PhD with at least 3 years of experience in Bioinformatics, Computer Science, Computational Biology or other closely related degree.
*Experience with biological datasets, preferably large scale genotyping and/or sequencing data preferred.
*Solid background in statistics, expertise in programming techniques and languages (R, Python, SAS).
*Experience with Unix/Linux environments (including shell scripting).
*Experience with Linus environment, high performance computing clusters, and cloud computing.
*Experience in next generation sequencing (NGS) analysis of DNA (eg. ChIP-seq, ATAC-seq), DNA interactions (eg. ChIA-PET, Hi-C), and gene expression (eg. RNA-seq, GRO-seq/PRO-seq.
*Experience with publicly available genetic databases (eg: GTEx, Roadmap, ExAC, USSC, GWAS catalog) preferred.
*Knowledge of cardiovascular disease preferred but not required.
SKILLS/ ABILITIES/ COMPETENCIES REQUIRED:
*Ability to work independently as well as part of a team.
*Possess strong analytical skills.
*Ability to prioritize assignments, multi-task, make decisions based upon sound principles, and independently problem solve.
*Possess managerial skills to interact with both with statistical staff, physician investigators and other members of the internal and external research group.
*Ability to draft plans to resolve inaccuracies or other problematic situations.
*Excellent verbal and written communication skills.
*Detail and process oriented.
*Ability to manage multiple projects simultaneously, including both long-term and short-term projects.
*Ability to make decisions related to issues in the statistical group pending final approval from the Director.
*Ability to develop novel ways to coordinate, manage and report data if required by new trials.
*Demonstrated sound independent judgment and competencies in clinical research.
Busy office environment with frequent deadlines.
**MEMBERS ONLY**SIGN UP NOW***. is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, sex, color, religion, national origin, sexual orientation, protected veteran status, or on the basis of disability.
Partner's Healthcare is acting as an Employment Agency in relation to this vacancy.
Position Type: Full-Time Permanent
Years of Experience Required: